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These agents are now being explored not only as a strategy to offset the side effects of GLP-1 analogs, but also as direct therapeutics for a range of metabolic disorders, including obesity and diabetes
however, it may be lowered to 50 mg or 25 mg once daily in cases of severe kidney impairment
Cardiovasc Ther 2022:6820377
Liver function tests may be required before and during the treatment to monitor the medicines effects
Here we show that a single administration of GLP-1 or GLP-1MK-801 elicits comparable reductions in the blood glucose levels in DIO mice, whereas equimolar MK-801 monotherapy does not acutely affect glycaemia (Fig
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